Polynucleotides: the latest breakthrough in Advanced Skin Booster Treatments

by | May 15, 2024

Polynucleotides and Advanced Skin Booster Treatments

You may have heard about Polynucleotides, the skin boosting and regenerative injectables that have been trending in recent months and have taken the Aesthetic industry by storm.

In this article, I will explore what exactly Polynucleotides are, along with the science behind them. I will also reveal their incredible benefits and how I believe they are set to revolutionize the way Aesthetic Practitioners approach advanced forms of skin rejuvenation, wrinkle reduction treatments and improving skin health and quality.


So, what are Polynucleotides ?

Polynucleotides are natural, highly purified molecules that are long chains of DNA ethically sourced from salmon. These highly purified fragments of DNA are suspended in water and available as a new and innovative injectable product.

When injected into the skin, these molecules penetrate deep into the dermal layers, and work by stimulating fibroblasts, which encourages cell turnover, improves elasticity, boosts collagen production and hydrates skin thanks to their powerful wound-healing polymers.

As Polynucleotides are a component predominantly derived from salmon DNA, it makes them natural, compatible and biodegradable. When using a polynucleotide product we are working exclusively with small fragments of DNA, that have undergone vigorous clinical filtration and ultra-purification.

This means even clients with fish allergies can safely use polynucleotides, as clinical trials have not reported any allergic reactions so far. It’s also worth noting that no salmon are harmed in the process of obtaining their DNA.

My view …

I would describe Polynucleotides as like a regenerative form of injectable advanced skin booster due to their multifaceted functioning.

They are becoming an increasing popular solution amongst clients seeking to “supercharge” their advanced skin care treatments as they play a role in both repairing and regenerating damaged / aged skin.

They are an advanced form of skin booster with several added benefits, as they work at a cellular level to start the skin’s own ability to rejuvenate itself, repair tissue whilst at the same time boosting skin quality.

Polynucleotides DNA Chain

The Science behind how Polynucleotides work ?

Polynucleotides are like a type of messenger that send signals to our skin cells to boost collagen and elastin production. As we get older, our ageing cells lose their ability to communicate effectively, leading to slower cell turnover and breakdown of key structural proteins like collagen and elastin.

Instead of providing an immediate boost in collagen and elastin or temporarily ‘plumping’ the skin like hyaluronic-based skin boosters and dermal fillers, polynucleotides serve as catalysts for regenerating fibroblasts, the key cells within the skin’s structural matrix.

Whilst ageing is an ongoing process, polynucleotides have the remarkable ability to rewind the clock in the treated areas.

Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA. These powerful molecules play a crucial role in the genetic code that determines how our cells function and replicate. By increasing cellular turnover and promoting collagen synthesis, these powerful compounds can help to improve skin texture, reduce fine lines and wrinkles, and restore overall radiance.

Each polynucleotide strand consists of a repeating pattern of a sugar molecule and a phosphate group. DNA and RNA represent the two main categories of nucleic acids. In simpler terms, these injectables essentially provide DNA molecules that encourage the skin to repair itself and promote various skin-boosting benefits, both immediately and for the long-term.

One of the key mechanisms by which polynucleotides work is through their ability to regulate gene expression within skin cells. By activating specific genes involved in cell growth and repair, these molecules can kickstart the natural processes that keep our skin looking youthful and healthy.

Furthermore, research has shown that polynucleotides have potent antioxidant properties, helping to protect against free radical damage and environmental stressors that contribute to premature aging. With their ability to promote both healing and protection at a cellular level, it’s no wonder why polynucleotides are gaining so much attention in the advanced skin care industry.

Polynucleotides lips before and after treatment

Polynucleotides are scientifically proven to:


    • Stimulate and boost collagen and elastin production.
    • Durably and efficiently repair the skin at a cellular level.
    • Hydrate the skin at a cellular level.
    • Improve tissue firmness and elasticity.
    • Have anti-inflammatory properties.
    • Promote cellular renewal.

So what makes injectable Polynucleotide treatments unique from other treatments such as Dermal Fillers?

Dermal fillers are designed to contour, augment and add volume to the skin. Results are usually instantaneous.

Polynucleotides work to stimulate fibroblasts at a cellular level to improve skin health; they have been scientifically proven to regenerate the skin from inside, at a cellular level, increasing the skin’s hydration levels, collagen production, skin elasticity and more.

Unlike traditional skin boosters that typically take around 3 months to see improvements, improvements in skin quality from polynucleotide treatments can be seen in just a few weeks (or when combined with hyaluronic acid, results can be seen instantly).

Polynucleotides go even further, by not just increasing hydration levels deep within, but also acting as a skin healer. Polynucleotides compliment the skin’s natural ability to self-repair by interacting directly with the fibroblasts and cells.

Benefits of Polynucleotides

Polynucleotides have emerged as a game-changer in the world of skin rejuvenation, due to their potential benefits for improving skin health and appearance.


    • Polynucleotides kickstart collagen production, the key to skin’s firmness and elasticity.
    • With their exceptional hydrating properties, Polynucleotides enhance moisture levels in your skin, ensuring a smoother and healthier complexion.
    • Polynucleotides have anti-inflammatory properties that calm and soothe the skin.
    • Polynucleotides are the skin’s best friend when it comes to wound healing. They promote tissue regeneration, reducing the appearance of acne scars, surgical scars and other types of skin damage, helping skin to recover faster
    • Polynucleotides act as antioxidants, shielding your skin from environmental stressors.
    • Polynucleotides promote enhanced tissue repair, by stimulating cell proliferation and promoting the regeneration of damaged tissues.
    • Polynucleotides are very versatile; they can be used to treat a variety of conditions and regions, including the face, neck, décolletage, upper arms, and scars, acne, stretch marks, and loss of elasticity in the face and neck, as well as crepey or drooping necks and under-eye shadows.
Polynucleotides Neck before and after Treatment

The Future of Polynucleotides in Advanced Skincare: Trends and Innovations

As we look to the future of advanced skin boosters, I am convinced that polynucleotides are set to play a crucial role in driving innovation and advancement in the aesthetics industry.

I am currently experimenting with the use of Polynucleotides in a combination regenerative treatment programme with Advanced Dermal fillers in my own Aesthetic Clinic.

If dermal fillers can restore volume, add hydration and structure then why not supercharge the results by adding polynucleotides to help repair dermal damage caused by ageing whilst at the same time promoting new cell growth and skin rejuvenation.


You can learn how to use Polynucleotides in my Advanced Skin Booster class. Click on the following link for details:



View Bookings